diff --git a/include/ui/clipboard.h b/include/ui/clipboard.h
index 2c6488c1ee..ce76aa451f 100644
--- a/include/ui/clipboard.h
+++ b/include/ui/clipboard.h
@@ -73,11 +73,13 @@ struct QemuClipboardPeer {
  * enum QemuClipboardNotifyType
  *
  * @QEMU_CLIPBOARD_UPDATE_INFO: clipboard info update
+ * @QEMU_CLIPBOARD_RESET_SERIAL: reset clipboard serial
  *
  * Clipboard notify type.
  */
 enum QemuClipboardNotifyType {
     QEMU_CLIPBOARD_UPDATE_INFO,
+    QEMU_CLIPBOARD_RESET_SERIAL,
 };
 
 /**
@@ -230,6 +232,13 @@ void qemu_clipboard_info_unref(QemuClipboardInfo *info);
  */
 void qemu_clipboard_update(QemuClipboardInfo *info);
 
+/**
+ * qemu_clipboard_reset_serial
+ *
+ * Reset the clipboard serial.
+ */
+void qemu_clipboard_reset_serial(void);
+
 /**
  * qemu_clipboard_request
  *
diff --git a/ui/clipboard.c b/ui/clipboard.c
index ffbd80e5c6..82572ea116 100644
--- a/ui/clipboard.c
+++ b/ui/clipboard.c
@@ -129,6 +129,13 @@ void qemu_clipboard_request(QemuClipboardInfo *info,
     info->owner->request(info, type);
 }
 
+void qemu_clipboard_reset_serial(void)
+{
+    QemuClipboardNotify notify = { .type = QEMU_CLIPBOARD_RESET_SERIAL };
+
+    notifier_list_notify(&clipboard_notifiers, &notify);
+}
+
 void qemu_clipboard_set_data(QemuClipboardPeer *peer,
                              QemuClipboardInfo *info,
                              QemuClipboardType type,
diff --git a/ui/cocoa.m b/ui/cocoa.m
index 6640a2e80e..7ca429fa80 100644
--- a/ui/cocoa.m
+++ b/ui/cocoa.m
@@ -1837,6 +1837,9 @@ static void cocoa_clipboard_notify(Notifier *notifier, void *data)
     case QEMU_CLIPBOARD_UPDATE_INFO:
         cocoa_clipboard_update_info(notify->info);
         return;
+    case QEMU_CLIPBOARD_RESET_SERIAL:
+        /* ignore */
+        return;
     }
 }
 
diff --git a/ui/gtk-clipboard.c b/ui/gtk-clipboard.c
index 44ff810234..e0b8b283fe 100644
--- a/ui/gtk-clipboard.c
+++ b/ui/gtk-clipboard.c
@@ -127,6 +127,9 @@ static void gd_clipboard_notify(Notifier *notifier, void *data)
     case QEMU_CLIPBOARD_UPDATE_INFO:
         gd_clipboard_update_info(gd, notify->info);
         return;
+    case QEMU_CLIPBOARD_RESET_SERIAL:
+        /* ignore */
+        return;
     }
 }
 
diff --git a/ui/vdagent.c b/ui/vdagent.c
index b4fdae6917..7ea4bc5d9a 100644
--- a/ui/vdagent.c
+++ b/ui/vdagent.c
@@ -466,6 +466,15 @@ static void vdagent_clipboard_update_info(VDAgentChardev *vd,
     }
 }
 
+static void vdagent_clipboard_reset_serial(VDAgentChardev *vd)
+{
+    Chardev *chr = CHARDEV(vd);
+
+    /* reopen the agent connection to reset the serial state */
+    qemu_chr_be_event(chr, CHR_EVENT_CLOSED);
+    qemu_chr_be_event(chr, CHR_EVENT_OPENED);
+}
+
 static void vdagent_clipboard_notify(Notifier *notifier, void *data)
 {
     VDAgentChardev *vd =
@@ -476,6 +485,9 @@ static void vdagent_clipboard_notify(Notifier *notifier, void *data)
     case QEMU_CLIPBOARD_UPDATE_INFO:
         vdagent_clipboard_update_info(vd, notify->info);
         return;
+    case QEMU_CLIPBOARD_RESET_SERIAL:
+        vdagent_clipboard_reset_serial(vd);
+        return;
     }
 }
 
diff --git a/ui/vnc-clipboard.c b/ui/vnc-clipboard.c
index 6a0b105884..d48f75eb1a 100644
--- a/ui/vnc-clipboard.c
+++ b/ui/vnc-clipboard.c
@@ -230,6 +230,9 @@ static void vnc_clipboard_notify(Notifier *notifier, void *data)
     case QEMU_CLIPBOARD_UPDATE_INFO:
         vnc_clipboard_update_info(vs, notify->info);
         return;
+    case QEMU_CLIPBOARD_RESET_SERIAL:
+        /* ignore */
+        return;
     }
 }